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研究表明,强力宁具有抗炎、抗过敏、保护四氯化碳及缺血再灌注所致的肝细胞损害作用,能增加单核细胞、NK细胞活性,诱导γ-干扰素的产生及抗病毒作用,但是否有抗纤维化作用,目前尚不完全清楚,体外及动物实验研究甘草酸在抗纤维化时有一定作用,但临床应用无报道,现研究强力宁的抗纤维化作用。 1 材料和方法 1.1 材料 无肝病及其他结缔组织增生性疾病对照组38例,男28例,女10例,平均年龄35岁,慢性肝炎66例,包括乙型肝炎57例,丙型肝炎9例,男48例,女18例,平均年龄36岁,诊断根据病理及临床,其中30例行肝穿刺,病理显示均有不同程度的肝纤维化。慢性肝炎患者分2组即强力宁治疗组(38例)及对照组(28例,只用一般护肝或加用肝炎灵),共随访8wk,每
Studies have shown that powerful Ning with anti-inflammatory, anti-allergy, protection of carbon tetrachloride and ischemia-reperfusion-induced liver cell damage can increase monocytes, NK cell activity, induction of γ-interferon and anti-virus However, whether there is anti-fibrosis, it is not yet fully understood, in vitro and animal experiments Glycyrrhizic acid in the anti-fibrosis have a role, but no clinical application reported, the study of anti-fibrosis Ning Ning effect. 1 Materials and methods 1.1 Materials Liver disease and other connective tissue hyperplasic diseases control group of 38 patients, 28 males and 10 females, mean age 35 years, 66 cases of chronic hepatitis, including 57 cases of hepatitis B, hepatitis C in 9 cases , 48 males and 18 females, with an average age of 36 years. According to the pathology and clinical diagnosis, 30 cases underwent liver biopsy. The pathological findings showed liver fibrosis with different degrees. Chronic hepatitis patients were divided into two groups, that is, the treatment group (n = 38) and the control group (n = 28), followed by 8wk