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目的:探讨中晚期膀胱癌化疗+膀胱灌注疗法的临床意义。方法:将2002年~2007年92例中晚期膀胱癌(T3-T4)病人随机分为:单纯化疗组46例,采用M-VAC方案,综合组46例,化疗同前组,合并膀胱灌注为DDP120mg/次,0.5小时变化1次体位,保留2小时。结果:全部病人随访5年以上,随访率97%,局控率综合组和单化组58.5%和41.5%(P>0.05)。综合组和单化组1、3、5生存率分别为81.1%、34.9%、20.1%和69.8%、24.6%、12.3%。3、5年生存率生存率差异有显著性(P>0.05)。结论:中晚期膀胱癌行化疗辅以膀胱灌注优于单纯化疗,是中晚期膀胱癌治疗的有效方法。
Objective: To investigate the clinical significance of bladder cancer chemotherapy + bladder irrigation in advanced stage. Methods: Ninety-two patients with intermediate and advanced stage bladder cancer (T3-T4) from 2002 to 2007 were randomly divided into chemotherapy group (n = 46), M-VAC regimen (n = 46), chemotherapy group DDP120mg / time, 0.5 hours change 1 position, keep 2 hours. Results: All the patients were followed up for more than 5 years. The follow-up rate was 97%. The rate of control group was 58.5% and 41.5% respectively (P> 0.05). The 1,3,5 survival rates were 81.1%, 34.9%, 20.1% and 69.8%, 24.6% and 12.3% respectively in the combination group and the singulation group. The 3-year and 5-year survival rates were significantly different (P> 0.05). Conclusions: Bladder cancer is better than chemotherapy alone in the treatment of advanced bladder cancer with chemotherapy combined with bladder irrigation. It is an effective method for the treatment of advanced bladder cancer.