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目的 观察静脉注射丙种球蛋白 (IVIG)对小儿全身炎症反应综合征 (SIRS)免疫功能的影响及临床疗效。方法 对符合诊断标准的 76例SIRS患儿随机分为治疗组 (39例 )和对照组 (37例 ) ,在基础治疗相同的情况下 ,治疗组给予IVIG按每次 40 0～ 10 0 0mg/kg ,每日 1次 ,连用 3d ,并于治疗前后测定Ig、CD4 、CD8、CD4 /CD8的变化。结果 IVIG治疗前后相比 ,IgG、CD4 、CD8及CD4 /CD8明显升高 (P <0 .0 5 )。与对照组相比 ,IVIG组疗效显著 (χ2 =7.5 2 ,P <0 .0 1) ,且无明显不良反应发生。结论 大剂量IVIG可调节SIRS患儿的免疫机制并改善其预后。
Objective To observe the effect and clinical effect of intravenous gamma globulin (IVIG) on immune function in children with systemic inflammatory response syndrome (SIRS). Methods Sixty-seven children with SIRS meeting the diagnostic criteria were randomly divided into treatment group (39 cases) and control group (37 cases). Under the same basic treatment, the treatment group received IVIG 40 ~ 100 mg / kg once daily for 3d, and the changes of Ig, CD4, CD8 and CD4 / CD8 were measured before and after treatment. Results The levels of IgG, CD4, CD8 and CD4 / CD8 were significantly increased before and after IVIG treatment (P <0.05). Compared with the control group, IVIG group was significantly effective (χ2 = 7.52, P <0.01), and no adverse reactions occurred. Conclusion High dose IVIG can regulate the immune mechanism of SIRS children and improve their prognosis.