Objective: To study the effect of Chaishao Jieyu Decoction on the improvement of mental state、immune function and diarrhea of Liver Depression and Spleen Deficiency patients with colorectal cancer after operation.Methods: 76 cases of colorectal cancer patients after operation, according to the method of random grouping would be divided into the chinese medicine treatment(CMT) group and the western medicine control (WMC)group, each group 38 cases.The WMC group were treated with montmorillonite. The CMT group accepted oral administration of Chaishao Jieyu Decoction. The levels of anxiety and depression score,quality of life,T lymphocyte subsets and TNF-α ,and improvement of diarrhea were compared. Results: With the therapy ending,the standards of SAS and SDS in CMT group were reduced signficantly than the WMC group(P<0.05),The score of QOL was obviously higher than the WMC group(P<0.05),the treatment group's CD3+、CD4+ subsets levels increased obviously than the WMC group(P<0.05),the CD8+ subsets and Tumor necrosis factor-alpha- levels were obviously lower than the WMC group(P<0.05), the improvement of diarrhea of the CMT group was obviously better than the WMC group (P<0.05). Conclusion: Chaishao Jieyu Decoction can effectively improve the mental state and diarrhea symptoms of postoperative patients with colorectal cancer, and significantly improve the immune function of the body,the Chaishao Jieyu Decoction's effect is excellent.