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目的探讨DNA倍体分析在脱落细胞学及宫颈癌早期诊断中的应用价值。方法收集参与该院宫颈癌普查的180例妇女的宫颈样本,分别进行Feulgen染色及巴氏染色,通过DNA倍体分析系统对Feulgen染色片进行扫描诊断,通过细胞学医师对巴氏染色片进行常规细胞学诊断,比较两种检测方式对宫颈癌早期诊断的应用价值。结果 DNA倍体分析特异性为65.63%,敏感性为78.85%;常规细胞学检查特异性为64.84%,敏感性为35.00%,其中两种检查方法的特异性相似,无统计学意义(χ2=0.14,p>0.05);敏感性具有明显差异,具有统计学意义(X2=39.21,p<0.05)。结论采用DNA倍体分析对适龄妇女进行宫颈癌筛查,能够提高宫颈癌的阳性检出率,适用于基层大规模开展,使用前景广阔,所以值得在临床推广。
Objective To investigate the value of DNA ploidy analysis in the diagnosis of exfoliative cytology and cervical cancer. Methods Cervical samples of 180 women who were involved in the cervical cancer screening of the hospital were collected and subjected to Feulgen staining and Papanicolaou staining respectively. The Feulgen stains were scanned by DNA ploidy analysis system. The cytology physicians performed routine Cytological diagnosis, comparison of two detection methods for cervical cancer early diagnosis value. Results The specificity of DNA ploid analysis was 65.63%, the sensitivity was 78.85%. The specificity of routine cytology was 64.84% and the sensitivity was 35.00%. The specificity of DNA ploid analysis was similar between the two methods (χ2 = 0.14, p> 0.05). There was significant difference between the two groups (X2 = 39.21, p <0.05). Conclusion DNA ploidy analysis of cervical cancer screening of women of the age can improve the positive detection rate of cervical cancer, suitable for large-scale grassroots development, the use of broad prospects, it is worth the clinical promotion.