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目的探讨神经胶质瘤HO-1 mRNA的表达及意义。方法通过荧光实时定量PCR法检测18例神经胶质瘤及癌旁组织HO-1 mRNA的表达。结果神经胶质瘤患者HO-1mRNA的表达水平(1.040±0.026)明显高于对照组(0.760±0.017)(P<0.05)。结论 HO-1 mRNA的表达在神经胶质瘤患者中明显升高,HO-1在神经胶质瘤发病过程中可起到保护作用。
Objective To investigate the expression and significance of HO-1 mRNA in glioma. Methods The expression of HO-1 mRNA in 18 gliomas and adjacent normal tissues was detected by real-time fluorescence quantitative PCR. Results The expression of HO-1mRNA in glioma patients (1.040 ± 0.026) was significantly higher than that in controls (0.760 ± 0.017) (P <0.05). Conclusion The expression of HO-1 mRNA is significantly increased in glioma patients, HO-1 may play a protective role in the pathogenesis of glioma.