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研究表明眼内血管形成刺激因子与抑制因子的失衡是糖尿病性视网膜病变(DR)发生的主要原因,而色素上皮源性因子(PEDF)是新近发现的一种重要的新生血管抑制物,可对抗病理性血管形成,同时具有神经营养及神经保护等其他作用。有研究表明糖尿病视网膜病变患者眼内PEDF表达发生改变,在DR的发生、发展过程中起一定的促进作用。就PEDF在DR中的表达及作用进行综述。
Studies have shown that imbalance of intravascular angiogenic stimulating factor and inhibitory factor is the main reason of diabetic retinopathy (DR), and pigment epithelial derived factor (PEDF) is a newly discovered important angiogenesis inhibitor that can antagonize Pathological vascular formation, both neurotrophic and neuroprotective and other effects. Studies have shown that diabetic retinopathy in patients with PEDF expression changes in the occurrence and development of DR play a role in promoting. The expression and role of PEDF in DR were reviewed.