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造血细胞的增殖受多种因子的调控 ,白血病的发生与基因的异常表达有关。Ｗｉｌｍｓ肿瘤基因(ＷＴ1)位于染色体 11ｐ13,编码一个具有激活和抑制双重功能的转录调控蛋白。ＷＴ1可以作用于许多与造血细胞增殖有关的基因 ,在不同的肿瘤发生和发展过程中起重要作用〔1、2〕。ＷＴ1在
The proliferation of hematopoietic cells is regulated by many factors, and the occurrence of leukemia is related to abnormal gene expression. The Wilms tumor gene (WT1) is located on chromosome 11p13 and encodes a transcriptional regulatory protein with dual functions of activation and inhibition. WT1 can act on many genes related to hematopoietic cell proliferation, play an important role in different tumorigenesis and development [1,2]. WT1 at