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采用放免技术测定36例急性,心肌梗塞(AMl)患者72小时血浆内皮素(ET)。发现AMI患者4小时后ET浓度明显高于对照组(P<0.05),6小时达高峰(59.38±4.51pg/ml,P<0.01),72小时后趋于下降。还发现血浆ET与左室射血分数(LVEF)之间有明显相关(P<0.05)。由此可见血浆ET在急性心肌梗塞发病中起着重要作用。
Radioimmunoassay was used to determine plasma endothelin (ET) level in 72 patients with acute myocardial infarction (AMl) for 72 hours. After 4 hours, the ET level in AMI patients was significantly higher than that in the control group (P <0.05), peaked at 6 hours (59.38 ± 4.51pg / ml, P <0.01), and then decreased after 72 hours. There was also a significant correlation between plasma ET and left ventricular ejection fraction (LVEF) (P <0.05). This shows that plasma ET plays an important role in the pathogenesis of acute myocardial infarction.