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正常情况下,人绒毛膜促性腺激素是胎盘产生的一种糖蛋白激素。怀孕2个月左右体内人绒毛膜促性腺激素浓度达高峰。胎盘的恶性肿瘤如绒癌、恶性葡萄胎患者体内人绒毛膜促性腺激素分泌异常增高。另外,某些肿瘤如睾丸癌等也常伴有人绒毛膜促性腺激素异常分泌。因此,人绒毛膜促性腺激素水平的测定对育龄妇女尽早知道自己是否已怀孕、绒癌、恶性葡萄胎及分泌人绒毛膜促性腺激素的肿瘤的早期诊断和术后观察至为重要。以往所采用的一些测定人绒毛膜促性腺激素的方法各有其不足之处,特别是不够简便快速。 北京协和医院内分泌科吴从愿教授等人经过多年的努力,采用淋巴细胞杂交瘤技术制备出多种高质量的抗人绒毛膜促性腺激素的单克隆抗体,并同
Under normal circumstances, human chorionic gonadotropin is a glycoprotein hormone produced by the placenta. About 2 months pregnant in vivo human chorionic gonadotropin concentration reached its peak. Malignant tumors of the placenta, such as choriocarcinoma, malignant hydatidiform mole patients with abnormal increased human chorionic gonadotropin secretion. In addition, some tumors such as testicular cancer are often accompanied by abnormal secretion of human chorionic gonadotropin. Therefore, the determination of human chorionic gonadotropin levels for women of childbearing age as soon as possible to know whether they are pregnant, choriocarcinoma, malignant mole and human chorionic gonadotropin secretion of the tumor early diagnosis and postoperative observation is important. Some of the methods used to measure human chorionic gonadotropins have their own shortcomings, especially not fast enough. Beijing Union Medical College Hospital Endocrinology Professor Wu Yuan-yuan, who after years of efforts, the use of lymphocyte hybridoma technology to prepare a variety of high-quality anti-human chorionic gonadotropin monoclonal antibody, and with