论文部分内容阅读
目的 :探讨CD90在胃癌组织中的表达及其临床意义。方法 :通过免疫组织化学双染法检测CD90在胃癌组织、癌旁组织和慢性胃炎组织中的表达,以研究其与胃癌临床病理因素及预后的关系。结果:CD90表达阳性率在胃癌组织中为66.7%(64/96),在癌旁正常组织中为15.6%(15/96),在慢性胃炎组织中为15.0%(3/20),差异有统计学意义(P<0.01);CD90在胃癌中的表达与TNM分期有关(P=0.014,PT=0.02,PN=0.017,PM=0.045;另外在多因素生存分析中,CD90高表达的患者均有更差的5年总生存率(P<0.05)。结论:CD90可能与胃癌的侵袭与转移相关,有可能为治疗提供一个新的分子靶点,并判断胃癌患者的预后。
Objective: To investigate the expression of CD90 in gastric carcinoma and its clinical significance. Methods: The expression of CD90 in gastric cancer tissue, paracancerous tissues and chronic gastritis tissues was detected by immunohistochemical double staining to study its relationship with clinicopathological factors and prognosis of gastric cancer. Results: The positive rate of CD90 expression was 66.7% (64/96) in gastric cancer tissues, 15.6% (15/96) in adjacent normal tissues and 15.0% (3/20) in chronic gastritis tissues. The difference was (P = 0.014, PT = 0.02, PN = 0.017, PM = 0.045). In addition, in the multivariate survival analysis, the expression of CD90 in gastric cancer was significantly higher than that in the control group (P <0.05) .Conclusion: CD90 may be involved in the invasion and metastasis of gastric cancer, which may provide a new molecular target for treatment and prognosis of patients with gastric cancer.