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目的:探讨肺滑膜肉瘤(Pulmonary Sgnovial Sarcoma)的病理组织学特点、诊断、鉴别诊断及预后。方法:对2例肺滑膜肉瘤手术切除标本进行光镜、免疫组织化学染色观察。结果:肺滑膜肉瘤组织学特点主要由梭形细胞构成,弥漫性紧密排列或呈交织束状排列;瘤细胞间含少量或无明显的胶原纤维,增生梭形细胞周见较多裂隙,核分裂像5-6个/HP。免疫表型:肿瘤细胞表达Vimentin、CK、EMA、Bcl-2及CD99,不表达CD68、actin、CD34、S100、desmin、mesothelial及Calretinin。结论:肺滑膜肉瘤是一种少见的肺部恶性肿瘤,有明显的病理组织学和免疫表型特点。
Objective: To investigate the pathological features, diagnosis, differential diagnosis and prognosis of pulmonary synovial sarcoma (Pulmonary Sgnovial Sarcoma). Methods: Two cases of resected specimens of pulmonary synovial sarcoma were observed by light microscopy and immunohistochemical staining. Results: The histological features of pulmonary synovial sarcoma consisted mainly of spindle cells, arranged diffusely closely or arranged in the form of intertwined bundles. The tumor cells contained little or no collagen fibers, and there were more fissures and mitoses in the spindle cells of proliferating cells Like 5-6 / HP. Immunophenotype: The tumor cells expressed Vimentin, CK, EMA, Bcl-2 and CD99, but did not express CD68, actin, CD34, S100, desmin, mesothelial and Calretinin. Conclusion: Pulmonary synovial sarcoma is a rare malignant tumor of the lung with obvious histopathological and immunophenotypic characteristics.