Zora Neale Hurston is an African-American novelist, anthropologist. Her famous novel Their Eyes Were Watching God to some extent reflects the pursuit of self-actualization of the female protagonist Janie. The psychological term Maslow’s Hierarchy of Needs is implemented in this study to help to analyze the process of Janie’s self-actualization, which illustrates how Janie realized self-fulfillment and appreciated the intrinsic worth of her surroundings and to experience the world deeply through marriages to three different men.