论文部分内容阅读
本文报道镉所致大鼠睾丸的即刻和延迟影响以及锌对抗镉损伤的超微结构变化。将44只大鼠分为单纯镉注射组(2 mg/kg体重)、镉和锌联合注射组(锌80 mg/kg体重),以及用生理盐水注射的对照组。注射镉后10～30分钟,部分精子细胞、精原细胞、初级精母细胞和曲细精管周组织,已出现超微结构改变;其中早期精子细胞和初级精母细胞损伤出现最早。睾丸毛细血管在1小时后才查见损伤改变。间质细胞的改变则在2～4小时后见到。3～7天后,生精上皮、曲细精管周组织和睾丸间质已普遍坏死。提示镉的损伤作用,包括对曲细精管的直接损伤和对睾丸血管的直接损伤两个方面,且血管损伤出现较晚。锌对于镉损伤的保护作用显著。但是对于早期精子细胞的保护作用,较其他各级生精细胞差些。
This article reports the immediate and delayed effects of cadmium-induced testicular toxicity in rats and ultrastructural changes of zinc against cadmium damage. Forty four rats were divided into two groups: cadmium injection group (2 mg / kg body weight), cadmium and zinc injection group (zinc 80 mg / kg body weight), and control group injected with saline. Ten to thirty minutes after injection of cadmium, ultrastructure changes have occurred in some spermatids, spermatogonia, primary spermatocytes and seminiferous tubules. The earliest damage occurs in early spermatids and primary spermatocytes. Testicular capillaries were not damaged until 1 hour later. Interstitial changes in the 2 to 4 hours to see. 3 to 7 days later, the seminiferous epithelium, seminiferous tubules and testicular interstitial tissue necrosis has been widespread. Prompted cadmium damage, including direct damage to the seminiferous tubules and direct damage to the testicular blood vessels in two aspects, and vascular injury later. Zinc has a significant protective effect against cadmium damage. However, the protection of early spermatogenic cells, compared with other levels of spermatogenic cells worse.