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目的研究动脉血压对肝素抗凝治疗效果的影响。方法回顾性分析应用肝素抗凝治疗急性脑梗死患者401例,对入院收缩压、舒张压,入院后1 d~5 d平均收缩压、平均舒张压,高血压病史及住院天数进行单因素或多因素分析。结果平均舒张压对改善率影响最大,无论是单因素分析(P=0.003),还是多因素回归分析(P=0.047),其统计结果均具有统计学意义,出院评分与平均收缩压关系(P=0.0 0 8)较平均舒张压(P=0.0 7 5)为强。7 d以下的住院改善率与7 d以上的住院改善率并没有差别(P=0.402)。改善率与高血压病史无相关性(P=0.084)。结论在肝素抗凝基础上,平均舒张压对改善率影响最大,与出院评分关系较强的为平均收缩压,住院天数、高血压病史在肝素抗凝的过程中未见影响效果。
Objective To study the effect of arterial blood pressure on the anticoagulant effect of heparin. Methods A retrospective analysis of 401 patients with acute cerebral infarction treated with heparin anticoagulation was performed. The systolic blood pressure, diastolic blood pressure, average systolic blood pressure, mean diastolic blood pressure, history of hypertension and days of hospitalization on day 1 ~ 5 after admission were analyzed by single factor or multiple Factor analysis. Results The average diastolic blood pressure had the strongest effect on the improvement rate. The statistical results were statistically significant both in univariate analysis (P = 0.003) and in multivariate regression analysis (P = 0.047). The relationship between discharge score and average systolic blood pressure (P = 0.0 0 8) than mean diastolic pressure (P = 0.0 7 5). There was no difference in hospitalization rates below 7 days and hospitalization rates above 7 days (P = 0.402). There was no correlation between improvement rate and the history of hypertension (P = 0.084). Conclusion On the basis of heparin anticoagulation, the average diastolic pressure has the strongest effect on the improvement rate. The average systolic blood pressure, hospitalization days and history of hypertension have no effect on the heparin anticoagulation.