论文部分内容阅读
目的：制备尼莫地平速释型固体分散体，增加其溶解度和溶解速度。方法：以聚乙烯吡咯烷酮（ＰＶＰ）、聚乙二醇６０００（ＰＥＧ６０００）和泊洛沙姆１８８（Ｐｏｌ１８８）为载体溶剂法和溶剂熔融法制备固体分散体，差热分析和Ｘ射线粉末衍射分析鉴别药物在载体中的存在状态，并进行体外溶出度研究。结果：尼莫地平在ＰＶＰ中以无定形存在，在ＰＥＧ６０００和Ｐｏｌ１８８中以微细结晶存在。载体比例越大，药物溶出愈快；比例相同时，Ｐｏｌ１８８尼莫地平固体分散体溶出最快，且载体比例愈小，差异愈显著。结论：Ｐｏｌ１８８作为尼莫地平固体分散体的载体，载药量大，增溶效果显著。
OBJECTIVE: To prepare nimodipine immediate release solid dispersion to increase its solubility and dissolution rate. Methods: The solid dispersions were prepared by polyvinylpyrrolidone (PVP), polyethylene glycol 6000 (PEG6000) and poloxamer 188 (Pol188) as solvent and solvent melting method. Differential thermal analysis and X-ray powder diffraction analysis The presence of the drug in the carrier and in vitro dissolution studies. Results: Nimodipine is amorphous in PVP and exists as fine crystals in PEG6000 and Pol188. The greater the proportion of carrier, the faster the drug dissolution; the same ratio, Pol188 Nimodipine solid dispersion dissolution fastest, and the smaller the carrier ratio, the more significant differences. Conclusion: As a carrier of nimodipine solid dispersion, Pol188 has a large drug loading and a significant solubilization effect.