采用RT—PCR方法,观察了-6°头低位卧床7d模拟做重力对热诱导的人外周血淋巴细胞中热休克蛋白70(hsp70)mRNA表达的影响.结果表明:常温条件下,模拟微重力组与对照相同;高温直立组和高温模拟做重力组hsp70mRNA表达均显著增加;但高温模拟做重力组明显低于高温直立组.提示模拟微重力可抑制热诱导的hsp70 mRNA表达.这种抑制作用可能是航天热应激时人体调节能力降低的机制之一. The effects of gravity on heat shock induced expression of heat shock protein 70 (hsp70) mRNA in human peripheral blood lymphocytes were observed by RT-PCR at-6 ° head-down bed for 7 days.The results showed that under normal temperature conditions, simulated microgravity Group and the control group; high temperature erection group and high temperature simulation do gravity group hsp70mRNA expression were significantly increased; but the high temperature simulation of the gravity group was significantly lower than the high temperature erection group.It suggests that simulated microgravity can inhibit heat-induced expression of hsp70 mRNA.This inhibition It may be one of the mechanisms that reduce the regulation ability of human body in aerospace thermal stress.