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目的:评价中西医结合治疗婴儿巨细胞病毒(cytomegalovirus,CMV)肝炎的临床疗效及安全性。方法:对中国知网数据库,维普中文科技期刊数据库,中国生物医学文献数据库,万方数据库,Pubmed,Cochrane图书馆进行检索。收集有关中西医结合治疗婴儿CMV肝炎的随机对照试验(randomized controlled trial,RCT),根据纳入和排除标准收集文献,进行Meta分析。结果:共纳入12篇RCT,Meta分析结果显示中西医结合治疗该病在总有效率、改善肝功能、促进肝脏回缩以及CMV病毒指标转阴率方面优于对照组。结论:中西医结合治疗婴儿CMV肝炎疗效优于单纯西医治疗,但纳入文献方法学质量普遍偏低,亟需更多高质量的临床试验进一步验证。
Objective: To evaluate the clinical efficacy and safety of integrated traditional Chinese and western medicine in the treatment of cytomegalovirus (CMV) hepatitis. Methods: The databases of CNKI, VIP database, Chinese biomedical literature database, Wanfang database, PubMed and Cochrane Library were searched. A randomized controlled trial (RCT) on CMV hepatitis B in Integrative Medicine was collected and the literature was collected according to inclusion and exclusion criteria for Meta-analysis. Results: A total of 12 RCTs were included in the study. The results of Meta analysis showed that the combination of TCM and WM was superior to the control group in terms of total effective rate, liver function improvement, hepatic retraction and CMV virus negative conversion rate. Conclusion: The curative effect of CMW on infants with CMV hepatitis is better than that of Western medicine alone. However, the quality of the included methodologies is generally low, and more high-quality clinical trials are needed to further verify.