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目的研究血清25-羟维生素D_3浓度与婴幼儿喘息的相关性。方法 95例喘息婴幼儿作为观察组,90例健康婴幼儿作为对照组,对两组婴幼儿进行血清25-羟维生素D_3浓度的检测,收集两组婴幼儿的基本资料,分析婴幼儿喘息发生的危险因素。结果观察组婴幼儿的血清25-羟维生素D_3浓度(21.8±6.2)ng/ml明显低于对照组(36.7±5.6)ng/ml,差异具有统计学意义(P<0.05)。两组年龄、性别比较差异无统计学意义(P>0.05),两组特应性体质、特殊环境、血清25-羟维生素D_3浓度、早产、父母过敏史比较差异具有统计学意义(P<0.05)。多因素分析显示,特应性体质、处于特殊环境、血清25-羟维生素D_3浓度<20ng/ml、父母有过敏史是引发婴幼儿喘息的独立危险因素(P<0.05)。结论婴幼儿喘息的发作与血清25-羟维生素D_3浓度低下存在显著相关性,加强对婴幼儿血清25-羟维生素D_3浓度的检测,及时发现异常婴幼儿,加强早期干预治疗,预防喘息的发生。
Objective To study the correlation between serum 25-hydroxyvitamin D 3 concentration and infant wheezing. Methods 95 cases of wheezing infants and young children as the observation group and 90 healthy infants as the control group, the two groups of infants and young children were measured serum 25-hydroxy vitamin D 3 concentrations were collected two sets of infants and young children’s basic information to analyze infant wheezing occurred Risk factors. Results The serum 25-hydroxyvitamin D3 concentration in infants and young children in observation group was significantly lower than that in control group (21.8 ± 6.2) ng / ml (36.7 ± 5.6) ng / ml, the difference was statistically significant (P <0.05). There was no significant difference between the two groups in age and sex (P> 0.05). There was significant difference in atherosclerosis, special environment, serum 25-hydroxyvitamin D 3 concentration, ). Multivariate analysis showed that the atopic constitution was in a special environment, serum 25-hydroxyvitamin D3 concentration <20ng / ml, allergic history of parents was an independent risk factor for infants and young children wheezing (P <0.05). Conclusion The onset of wheezing in infants and young children is significantly correlated with the low serum 25-hydroxyvitamin D 3 concentration. The detection of serum 25-hydroxyvitamin D 3 in infants and young children is strengthened, and abnormal infants and young children are detected in time. Intensive early intervention and early onset of wheezing are prevented.