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5. Semi-automated synthesis, validation and microPET imaging of 18F-FP-DTBZ as a vesicular monoamine t

Semi-automated synthesis, validation and microPET imaging of 18F-FP-DTBZ as a vesicular monoamine t

来源 :核技术：英文版 | 被引量 : 0次 | 上传用户：cnzhchch

【摘 要】

：

This work was to develop a semi-automated synthesis of 18F-9-fluoropropyl-9-desmethyl-DTBZ (18F-FP-DTBZ) and validate its potential as a vesicular monoamine tra

【作 者】

：

CHEN Zhengping LIU Chunyi LI x 

【机 构】

：

KeyLaboratoryofNuclearMedicine

【出 处】

：

核技术：英文版

【发表日期】

：

2012年1期

【关键词】

：

半自动化 转运蛋白 成像质量 合成 验证 单胺 囊泡 放射化学纯度 VMAT2  Imaging agent  18F-FP-DTBZ  Synthesis 

【基金项目】

：

Supported by the National Natural Science Foundation of China （30970844）, the Outstanding Medical Professionals Foundation of Jiangsu Province （RC2011096） and Natural Science Foundation of Jiangsu Pro

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论文部分内容阅读

This work was to develop a semi-automated synthesis of 18F-9-fluoropropyl-9-desmethyl-DTBZ (18F-FP-DTBZ) and validate its potential as a vesicular monoamine transporter 2 (VMAT2) ligand.18F-FP-DTBZ was synthesized by a semi-automated procedure in a 21-35%

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