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类风湿关节炎(RA)的基本病理改变为滑膜慢性炎症和破坏骨、软骨的侵袭性血管翳形成。这一过程中,血管新生起到了关键作用,血管生成素-1(Ang- 1)是近年发现的促血管生成因子,具有促进血管形成、维持血管稳定和促进细胞增殖的作用。本研究旨在探讨生血管成素-1与RA发病机制的关系。
The basic pathological changes of rheumatoid arthritis (RA) are chronic synovial inflammation and invasive angiogenesis that disrupts bone and cartilage. In this process, angiogenesis played a key role. Angiopoietin-1 (Ang-1) is an angiogenic factor discovered in recent years and has the function of promoting blood vessel formation, maintaining blood vessel stability and promoting cell proliferation. This study aimed to investigate the relationship between Angiopoietin-1 and the pathogenesis of RA.