菌必治钠作为第三代头孢菌素,在体外试验对绿色链球菌和非肠球菌性链球菌有极强的活性作用。它的半衰期为6～9小时,菌必治用药每日1次肌注或静注,能保持血清有效水平24小时。本研究的目的在于检验单用菌必治钠2克每日1次肌注或短期静脉输注(共4周),治疗菌必治敏感的链球菌性心内膜炎的效果和安全性。研究选用59例确诊为链球菌性心内膜炎,其中41例男性,18例女性,年龄中值为59(19～87)岁,治疗前症状持续时间为5～120天。其中56例病人有瓣膜或先天性心脏畸形。感染单独影响二尖瓣者28人(占47%),单独影响主动脉瓣者20人(占34%),同时影响二尖瓣和主动脉瓣者5人(占8%),影响肺动脉瓣者2 Bacillus subtilis sodium as the third generation cephalosporin, in vitro tests on Streptococcus agalactiae and non-enterococci Streptococcus has a strong activity. Its half-life of 6 to 9 hours, the bacteria must be treated once daily intramuscular or intravenous injection, to maintain serum levels of 24 hours. The purpose of this study was to examine the efficacy and safety of single-dose, 2-mg sodium therapy administered intramuscularly or short-term intravenously (4 weeks) once daily to treat susceptible streptococcal endocarditis. Fifty-nine patients were diagnosed as streptococcal endocarditis, including 41 males and 18 females. The median age was 59 (19-87) years. The duration of symptoms before treatment was 5 to 120 days. Of these 56 patients had valvular or congenital heart defects. Infection alone affected 28 (47%) with mitral valve disease, 20 (34%) with aortic valve involvement alone, and 5 (8%) with mitral and aortic valve involvement affecting the pulmonary valve 2