复发性流产(recurrent miscarriage,RM)是指连续发生2次或2次以上的流产,在妊娠妇女中发病率约为1%。有复发性流产史的女性,再次怀孕发生流产的风险在35-39岁时约为40%,至40-44岁时升至60%。研究发现,80%的流产病因仍是不明确的,这意味着可能与遗传因素有关。有复发性流产史的夫妇,约3%存在染色体异常,这部分人需要进行遗传咨询,并应检测所孕胎儿的染色体核型。1单基因突变单基因突变可能是导致复发性流产的病因之一。如2004年,Kovalevsky等研究发现,人群中的凝血因子Ⅴ和凝血酶原基因(G20210A)的突变率接近5%,而有RM史的夫妇发生突变的可能性高达10%,她们患遗传性凝血障碍的几 Recurrent miscarriage (RM) refers to two or more consecutive abortions, with a prevalence of approximately 1% in pregnant women. Women who have a history of recurrent miscarriage have a 40% risk of miscarriage after 35-39 pregnancies and 60% by age 40-44. The study found that 80% of the causes of abortion is still not clear, which means that may be related to genetic factors. About 3% of couples with recurrent spontaneous abortion have chromosomal abnormalities, some of whom require genetic counseling and should examine the chromosomal karyotype of the pregnant fetus. A single gene mutation Single gene mutation may be one of the causes of recurrent spontaneous abortion. For example, in 2004, Kovalevsky et al. Found that the mutation rate of clotting factor Ⅴ and prothrombin gene (G20210A) in the population is close to 5%, while those with RM history are 10% more likely to have mutations. They have hereditary coagulation How many obstacles?