2013年7月26日,Science刊登了浙江大学生命科学研究院叶升课题组的研究论文,解析了细胞分裂蛋白FtsZ所形成的原丝纤维的三维结构,这将为广谱抗生素的研发提供依据。该课题组从结核分枝杆菌中克隆了FtsZ的基因,通过X射线衍射,拍下了100多张不同角度的FtsZ蛋白晶体衍射图,第一次看到了这样的景象:GTP水解后,FtsZ原丝纤维发生了50度的弯曲。原来,FtsZ蛋白的顶端有一处非常“柔软”的部分,课 On July 26, 2013, Science published a research paper by Ye Sheng from Zhejiang University Institute of Life Sciences, and analyzed the three-dimensional structure of protofilament formed by FtsZ, which will provide the basis for the development of broad-spectrum antibiotics . The team cloned the FtsZ gene from Mycobacterium tuberculosis. By X-ray diffraction, we took more than 100 crystal diffraction patterns of FtsZ protein at different angles. For the first time, we can see that FtsZ The fiber has undergone a 50 degree bend. It turned out that the top of the FtsZ protein has a very “soft” part of the class