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目的观察放疗同步紫杉醇(PTX)、顺铂(DDP)方案治疗晚期食管癌的疗效,为食管癌的临床治疗提供最佳的方案。方法 30例晚期食管癌患者,随机分为对照组和治疗组,每组15例。对照组采用紫杉醇和顺铂联合治疗,治疗组采用放疗同步紫杉醇、顺铂联合治疗,观察两组的疗效及不良反应情况。结果对照组和治疗组的有效率分别为66.7%和46.7%,比较差异有统计学意义(P<0.05);两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论放疗同步紫PTX、DDP方案治疗晚期食管癌有显著疗效,且未增加不良反应,值得推广应用。
Objective To observe the curative effect of concurrent paclitaxel (PTX) and cisplatin (DDP) regimen in the treatment of advanced esophageal cancer and provide the best solution for the clinical treatment of esophageal cancer. Methods Thirty patients with advanced esophageal cancer were randomly divided into control group and treatment group, 15 cases in each group. The control group was treated with paclitaxel and cisplatin. The treatment group was treated with paclitaxel and cisplatin combined with radiotherapy. The curative effect and adverse reactions of the two groups were observed. Results The effective rates of the control group and the treatment group were 66.7% and 46.7%, respectively, with statistical significance (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusions Radiotherapy synchronization PTX, DDP regimen has a significant effect in the treatment of advanced esophageal cancer, and does not increase adverse reactions, it is worth popularizing and applying.