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目的:探讨血清铁调素(Hepcidin)在老年人群缺铁性贫血(IDA)和慢性病贫血(ACD)中的应用价值。方法:选择老年IDA患者32例,老年ACD患者34例,健康对照组28例。检测对比三组血清Hepcidin、血清铁(SI)、血清铁蛋白(SF)、C-反应蛋白(CRP)、红细胞数(RBC)、血红蛋白(Hb)、红细胞比容(HCT)、红细胞平均体积(MCV)、白细胞数(WBC)水平。结果:ACD组中WBC明显高于IDA组(P<0.05)。血清Hepcidin在IDA组、ACD组及对照组之间具有显著性差异(P<0.05),IDA组中Hepcidin含量比对照组低,而ACD组中Hepcidin含量比对照组高(P<0.05)。IDA组、ACD组中SI明显低于对照组(P<0.05),而两组间无显著性差异(P>0.05)。ACD组中SF、CRP均明显高于IDA组与对照组(P<0.05)。Hepcidin诊断IDA组的ROC曲线下面积(AUC)值大于诊断ACD组,IDA组的诊断指数高于ACD组。结论:血清Hepcidin含量的检测对于鉴别IDA和ACD具有重要的意义。
Objective: To investigate the value of serum Hepcidin in the elderly with iron deficiency anemia (IDA) and chronic anemia (ACD). Methods: 32 elderly IDA patients, 34 elderly ACD patients and 28 healthy controls were selected. The levels of serum Hepcidin, serum iron, serum ferritin, CRP, RBC, Hb, HCT, mean volume of erythrocyte MCV), white blood cell count (WBC) levels. Results: The WBC in ACD group was significantly higher than that in IDA group (P <0.05). Serum Hepcidin was significantly different between IDA group, ACD group and control group (P <0.05). The content of Hepcidin in IDA group was lower than that in control group, while the content of Hepcidin in ACD group was higher than that in control group (P <0.05). SI in IDA group and ACD group was significantly lower than that in control group (P <0.05), but there was no significant difference between the two groups (P> 0.05). The levels of SF and CRP in ACD group were significantly higher than those in IDA group and control group (P <0.05). Hepcidin diagnosis IDA group under the area under the ROC curve (AUC) value is greater than the diagnosis of ACD group, IDA group diagnostic index was higher than the ACD group. Conclusion: The detection of serum Hepcidin content is of great significance for the identification of IDA and ACD.