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目的探讨辛伐他汀联合氯吡格雷治疗颈动脉粥样硬化斑块(CAAP)的临床疗效。方法将70例入选患者随机分为两组:治疗组34例(辛伐他汀联合氯吡格雷+常规内科治疗),对照组36例(常规内科治疗)。入组患者均于治疗前后进行颈动脉彩色多普勒超声检查,对CAAP内膜-中层厚度(IMT)、CAAP积分评估。结果治疗组疗效明显优于对照组(P<0.05)。结论辛伐他汀联合氯吡格雷治疗CAAP疗效优于常规内科治疗。
Objective To investigate the clinical efficacy of simvastatin combined with clopidogrel in the treatment of carotid atherosclerotic plaque (CAAP). Methods Seventy patients were randomly divided into two groups: the treatment group 34 cases (simvastatin combined with clopidogrel + conventional medical treatment), the control group 36 cases (conventional medical treatment). All the patients in the study group were examined carotid color Doppler echocardiography before and after treatment, and evaluated CAAP intima-media thickness (IMT) and CAAP. Results The treatment group was significantly better than the control group (P <0.05). Conclusion Simvastatin combined with clopidogrel is superior to conventional medical therapy in the treatment of CAAP.