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目的探讨慢性乙型肝炎患者血清HA、PCⅢ水平与肝组织病理炎症分级纤维化分期的关系。方法采用放射免疫法检测111例慢性乙型肝炎患者血清HA、PCⅢ水平,并与肝组织病理炎症分级和纤维化分期结果相比较。结果血清HA、PCⅢ水平随着肝脏病理炎症活动及纤维化程度加重而增高。结论联合检测血清HA、PCⅢ水平是反映肝脏炎症和纤维化的良好指标。
Objective To investigate the relationship between the levels of serum HA and PCⅢ in patients with chronic hepatitis B and the stage of fibrosis staging of pathological inflammation in chronic hepatitis B patients. Methods The serum levels of HA and PCⅢ in 111 patients with chronic hepatitis B were detected by radioimmunoassay. The levels of serum HA and PCⅢ were compared with those of histological grade and fibrosis stage. Results The levels of serum HA and PCⅢ increased with the increase of liver pathological inflammation and fibrosis. Conclusion The combined detection of serum HA and PCⅢ levels is a good indicator of liver inflammation and fibrosis.