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花生四烯酸的代谢中存在一种起关键作用的酶-环氧化酶,它存在两种亚型:COX-1和COX-2,这两种亚型的生物学作用存在差异。研究发现血管内皮细胞通过产生内皮源性收缩因子(ED-CFs)引起内皮依赖性收缩,引起内皮依赖性收缩的主要物质是COX-1催化生成的前列腺素类物质,它们通过激活血管平滑肌细胞上的血栓素-前列腺素(TP)受体来启动血管收缩过程,所以COX-1在此过程中起着主导作用。衰老、高血压、糖尿病都可以促进内皮依赖性收缩,这一促进作用可以引起血管内皮功能障碍,造成血管疾病。
There is a key enzyme in the metabolism of arachidonic acid - cyclooxygenase, which exists in two subtypes: COX-1 and COX-2, the biological effects of these two subtypes are different. The study found that endothelial cells produce endothelium-dependent contraction by generating endothelium-derived contraction factor (ED-CFs), the main substance that causes endothelium-dependent contraction is COX-1-catalyzed prostaglandins that activate vascular smooth muscle cells Of thromboxane-prostaglandin (TP) receptors to initiate vasoconstriction, COX-1 plays a dominant role in this process. Aging, high blood pressure, diabetes can promote endothelium-dependent contraction, which can promote vascular endothelial dysfunction, causing vascular disease.