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目的分析糖尿病合并葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏症患者溶血的原因,为临床药师对此类患者的药学监护提供参考。方法通过参与3例初发2型糖尿病合并G-6-PD缺乏性溶血患者的治疗方案制定,对患者的溶血原因进行分析,介绍临床药师协助医师制定药物治疗方案、实施药学监护的过程。临床药师将治疗药物的选择和药物不良反应(ADR)监测作为切入点,开展药学监护。结果糖尿病合并G-6-PD缺乏症患者的溶血反应很可能与高血糖状态和血塞通注射液、舒血宁注射液等中药注射剂的使用相关。结论对糖尿病合并G-6-PD缺乏症的患者,临床药师尤其应注意可引起溶血的药物因素,为此类患者开展药学监护有助于提高用药方案的有效性和安全性。
Objective To analyze the causes of hemolysis in patients with diabetes and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and provide reference for the pharmacological care of such patients by clinical pharmacists. Methods Through the treatment of 3 patients with newly diagnosed type 2 diabetes mellitus complicated with G-6-PD deficiency hemolysis, the cause of hemolysis was analyzed. The clinical pharmacist was introduced to assist the physician to make the drug treatment plan and carry out the pharmacy care. Clinical pharmacists use therapeutic drug selection and adverse drug reaction (ADR) monitoring as a starting point for pharmacy care. Results Hemolytic reaction in patients with diabetes mellitus and G-6-PD deficiency is likely to be related to hyperglycemia and the use of traditional Chinese medicine injections such as Xuesaitong Injection and Shuxuening Injection. Conclusion In patients with diabetes mellitus and G-6-PD deficiency, clinical pharmacists should pay particular attention to the factors that can cause hemolysis. To carry out the medical supervision of such patients helps to improve the efficacy and safety of the drug regimen.