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目的研究2012~2013年我院多重耐药鲍曼不动杆菌(MDRAB)的感染分布特征及耐药性变化，为临床合理应用抗菌药物提供依据。方法采用法国梅里埃VITEK2/Compact全自动细菌培养鉴定仪进行细菌鉴定，采用纸片扩散法(K-B)进行药物敏感试验，药敏结果以CLSI2012版标准进行判读。结果2012年MDRAB检出率为25.8%，2013年检出率为16.08%，检出率略有下降但差异无统计学意义；2012年医院感染的MDRAB主要分布在呼吸内科(32.3%)、ICU(25.8%)和神经外科(16.1%)，2013年主要分布神经外科(39.1%)、ICU(17.4.0%)和呼吸内科(13.0%)，标本来源主要以痰液为主，分别为90.6%和91.3%。 MDRAB对常用25种抗菌药物的耐药率，除对粘菌素、米诺环素、头孢哌酮/舒巴坦的耐药率较低外，其余都在50%以上，对其中9种抗菌药物的耐药率为100%。结论通过我院对多重耐药菌医院感染的严格管理，2013年MDRAB检出率较2012年有下降趋势，大部分抗菌药物的耐药率也在下降。临床应继续重视MDRAB的感染，合理使用抗菌药物，加强消毒隔离，以更好地预防MDRAB的发生与播散。“,”Objective The changes of clinical distribution and drug resistance of multidrug resistant Acinetobacter baumanni (MDRAB)in the hospital in 2012~2013 were Studied in order to provide a foundation for rational administration of antimicrobial drugs.Methods The strain identification were performed by using VITEK-2 compact identification system and antimicrobial susceptibility testing were car ied out by means of Kirby-Bauer method.The data were analyzed by WHONET 5.6 software according to CLSI 2012 breakpoints.Results The detection rate of MDRAB was 25.83%in 2012,and 16.08%in 2013.The ratio declined slightly,with no statistical significance.MDRAB strains were mainly isolated from respiratory disease Department (32.3%/13.0),neurosurgical department (16.1%/39.1%)and neurosurgical intensive care unit(25.8%/17.4).The major specimens of MDRAB was sputum(90.6/91.3).MDRAB isolates showed the lowest resistant rates to Colistin,Minocycline and Cefoperazone/Sulbactam in the 25 kinds of commonly used antimicrobial drugs.The resistant rates of other antimicrobial agents were higher than 50.0%.The resistant rates to 9 kinds of drug resistance rate was 100%.Conclusion Through the strict management of multidrug resistant bacteria in hospital infection,the detection rate of MDRAB is decreased,the majority of antimicrobial resistance rates have dropped in.Clinical should continue to at ach importance to MDRAB infections,the rational use of antimicrobial drugs,to strengthen disinfection and isolation,in order to bet er prevent occur ence and spread of MDRAB.