对 38例狼疮肾炎 (LN)患者行活检 ,对两组肾小管间质损害的不同程度及肾功能进行观察。结果发现 :31例有不同程度的肾小管间质损害 ,其中以病理Ⅳ型常见 ,肾小管以多灶肾间质损害为多 ,受累面积在 30 %～ 70 %。尿RBC、Scr,Ccr等不同。提示肾小球间质损害与临床肾功能减退、血尿有密切联系。狼疮肾炎肾小球的病理类型及其严重程度可以有各种情况。 Thirty-eight patients with lupus nephritis (LN) underwent biopsy. The degree of tubulointerstitial damage and renal function in the two groups were observed. The results showed that: 31 cases had different degrees of tubulointerstitial damage, of which pathological type Ⅳ is common, renal tubules with multiple lesions of renal interstitium are more involved in the area of ​​30% to 70%. Urine RBC, Scr, Ccr and so different. Prompt interstitial glomerular damage and clinical renal dysfunction, hematuria are closely linked. Lupus nephritis, the pathological type of glomerular and its severity can have a variety of circumstances.