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用病人血清或先前接种了病人血清的黑猩猩的血清接种,十只黑猩猩感染了非甲、非乙型肝炎。在间接萤光试验(IF)中,其中一只黑猩猩的恢复期血消同自身的肝活检标本以及其余黑猩猩中8只的标本切片的肝细胞核超反应。同样,和一恢期病人血清起反应。这些阳性血清不和未感染的黑猩猩的肝切片起反应。未感染或已有抗甲型或乙型肝炎抗原的抗体的黑猩猩血清同阳性肝切片无反应。这些对照的结果暗示,查到的抗原—抗体系统对非甲、非乙型肝炎有特异性。
Ten chimpanzees were infected with non-A, non-B hepatitis by sera from patient serum or chimpanzee previously vaccinated with patient serum. In the Indirect Fluorescence Test (IF), convalescent blood loss in one of the chimpanzees was hypersensitive to hepatocyte nuclei in their own liver biopsy specimens and in 8 of the other chimpanzees. Again, react with a patient’s serum recovery. These positive sera do not respond to liver sections of uninfected chimpanzees. The chimpanzee serum of uninfected or existing antibodies against hepatitis A or B antigen did not respond to positive liver sections. The results of these controls suggest that the antigen-antibody system detected is specific for non-A, non-B hepatitis.