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目的:分析糖化血红蛋白(HbA1c)与凝血4项检测在2型糖尿病(T2DM)合并微血管病变患者中的应用价值。方法:选择2015年9月至2016年12月就诊于东莞市第三人民医院的T2DM患者150例,根据是否合并微血管病变将所有患者分为两组,其中观察组90例,合并微血管病变;对照组60例,无微血管病变。比较两组空腹血糖(FBG)、HbA1c水平与凝血4项指标。结果:观察组FBG、HbA1c与纤维蛋白原(FIB)明显高于对照组,活化部分凝血活酶时间(APTT)明显短于对照组,差异有统计学意义(P<0.05);两组凝血酶原时间(PT)与凝血酶时间(TT)相比,差异无统计学意义(P>0.05)。结论:HbA1c、PT、APTT、FIB及TT检测有助于早期发现T2DM患者合并微血管病变,为临床及时掌握病情进展、制定防治方案提供重要的指导价值。
Objective: To analyze the value of detecting HbA1c and coagulation in 4 patients with type 2 diabetes mellitus (T2DM) with microvascular disease. Methods: A total of 150 T2DM patients treated in Dongguan Third People’s Hospital from September 2015 to December 2016 were enrolled. All patients were divided into two groups according to whether they had microangiopathy or not. The observation group consisted of 90 patients with microangiopathy. Group of 60 cases, no microvascular disease. Fasting blood glucose (FBG), HbA1c levels and coagulation were compared between the two groups. Results: The FBG, HbA1c and fibrinogen (FIB) in the observation group were significantly higher than those in the control group, and the APTT was significantly shorter in the observation group than in the control group (P <0.05). The levels of thrombin There was no significant difference between the original time (PT) and the thrombin time (TT) (P> 0.05). Conclusion: The detection of HbA1c, PT, APTT, FIB and TT can be helpful for the early detection of patients with T2DM complicated by microvascular disease. It provides an important guideline for clinical diagnosis of disease progression and prevention and treatment plan.