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伴有高免疫球蛋白血症 M 的免疫缺陷是一个综合征,它的特征是正常到高水平的血清 IgM,低水平甚至缺(?)的 IgG 和 IgA。这种综合征的缺陷,被认为是存在于 B 细胞中,是 B 细胞不能进行一个将 IgM 转至 IgG 或IgA 的一种免疫类型的开关过程所致。为了更直截了当地阐明此问题,作者将9例患有该综合征的病人的B 细胞与美洲商陆有丝分裂剂培养,同时加入开关 T细胞或正常对照 T 细胞。在与正常 T 细胞培养时,B细胞只分泌 IgM,而与开关 T 细胞培养时,B 细胞既分泌 IgM 又分泌 IgG,或分泌 IgM,IgG 和 IgA。此外,用稳定区或开关区基因探针的方法,对这些 B 细胞免疫球蛋白重链基因的分析表明,其基因型是正常的。这些资料表明,高免疫球蛋白血症 M 病人的 B 细胞,正如作者以前所认识的那样是正常的,此外,至
The immunodeficiency associated with hyper-immunoglobulinmia M is a syndrome characterized by normal to high levels of serum IgM, low levels of IgG and IgA, even missing. The deficiency of this syndrome is thought to occur in B cells, an immune-type switch process in which B cells fail to switch IgM to IgG or IgA. To clarify this issue more straightforwardly, the authors cultured B cells from 9 patients with this syndrome with pollination pokeweed, along with either switch T cells or normal control T cells. When cultured with normal T cells, B cells secrete only IgM, whereas with switch T cells, B cells secrete both IgM and IgG, or IgM, IgG and IgA. In addition, the analysis of these B-cell immunoglobulin heavy chain genes by using stable region or switch region gene probes revealed that their genotypes are normal. These data suggest that B cells from patients with hyperimmunoglobulinemia M are normal as previously recognized by the authors and in addition to