放射性核素标记的抗体已试用于临床扫描定位恶性肿瘤,但因与肿瘤组织结合的特异性差,故而限制了其临床应用。单克隆抗体与相应肿瘤抗原有很高的特异性,所以有希望提高肿瘤扫描诊断的阳性率。本实验用~(131)I标记的特异作用于人黑色素瘤表面相关抗原(P_(97))的单克隆抗体和该抗体的Fab片段,探讨了其扫描诊断人黑色素瘤的可能性。 Radionuclide-labeled antibodies have been used in clinical scans to locate malignancies, but their specific application to tumor tissue has been limited, which limits their clinical application. Monoclonal antibodies and the corresponding tumor antigens have high specificity, so there is hope to increase the positive rate of tumor scan diagnosis. In this experiment, a monoclonal antibody specific for human melanoma surface-associated antigen (P_97) was labeled with 131I and the Fab fragment of this antibody was used to investigate the possibility of its scanning for the diagnosis of human melanoma.