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用胡椒醛、乙酰乙酸乙酯和醋酸铵在微波辐射下干反应得4-胡椒基-2,6-二甲基-3,5-乙氧羰基-1,4-二氢吡啶 1(C20H23NO6),4-胡椒基-2,6-二甲基-3,5-乙氧羰基-1,4-二氢吡啶在NDC (烟酸三氧化铬) 存在下经微波辐射得到4-胡椒基-2,6-二甲基-3,5-乙氧羰基吡啶 2 (C20H21NO6)。产物的结构通过单晶X-射线衍射法确定, 1 属单斜晶系, 空间群P21/c, a = 14.864(3), b = 9.830(1), c = 14.517(3)? b = 115.25(1), V = 1918.6(6)?, Z = 4, Mr = 373.39, Dc = 1.293g/cm3, m(MoKa)=0.096mm-1, F(000)=792。最终的偏离因子为R = 0.0496, wR = 0.1368。2 属三斜晶系,空间群Pī, a = 8.915(1), b = 10.575(1), c = 11.904(1)?α = 102.19(1),b = 109.43(1),γ=108.94(1), V=934.79(16) 3, Z = 2, Mr = 371.38, Dc = 1.319g/cm3 , m(MoKa) = 0.098mm-1, F(000) = 392。最终的偏离因子为R=0.0412, wR=0.1011。1 的二氢吡啶环为信封式结构, 2的吡啶环为平面结构。
Drying with piperonal, ethyl acetoacetate and ammonium acetate under microwave irradiation gave 4-piperonyl-2,6-dimethyl-3,5-ethoxycarbonyl-1,4-dihydropyridine 1 (C20H23NO6) , 4-piperonyl-2,6-dimethyl-3,5-ethoxycarbonyl-1,4-dihydropyridine was microwave-irradiated in the presence of NDC (nicotinic acid chromium trioxide) to give 4-piperonyl-2 , 6-dimethyl-3,5-ethoxycarbonylpyridine 2 (C20H21NO6). The structure of the product was confirmed by single crystal X-ray diffraction. One is monoclinic, space group P21 / c, a = 14.864 (3), b = 9.830 (1), c = 14.517 (3) (1), V = 1918.6 (6) ?, Z = 4, Mr = 373.39, Dc = 1.293 g / cm3, m (MoKa) = 0.096 mm-1, F (000) = 792. The final deviations are R = 0.0496 and wR = 0.1368.2, respectively. The triclinic system has space group Pī, a = 8.915 (1), b = 10.575 (1), c = 11.904 , b = 109.43 (1), γ = 108.94 (1), V = 934.79 (16) 3, Z = 2, Mr = 371.38, Dc = 1.319g / cm3, m (MoKa) = 0.098mm-1, F (000) = 392. The final deviation factor is R = 0.0412, the dihydropyridine ring with wR = 0.1011.1 is in the envelope structure, and the pyridine ring in 2 is in the planar structure.