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目的探讨孕三烯酮治疗中、重度子宫内膜异位症(EMS)的疗效。方法确诊EMS患者70例,随机分为三组:A组(23例)自月经第1天起口服孕三烯酮2.5mg,每周2次;B组(23例)口服孕三烯酮2.5mg,每周3次;C组(24例)口服孕三烯酮2.5mg,每周3次,同时加服保肝药甘草酸二铵胶囊150mg,每天3次,连续服用3个月。观察三组阴道不规则出血、痛经、慢性盆腔痛、性交痛的改善情况,测定血清癌抗原125(CA125)、雌二醇(E2)、卵泡刺激素(FSH)和黄体生成素(LH)。结果与治疗前比较,三组患者治疗后的疼痛症状均减轻,阴道不规则出血减少,血清CA125、E2、FSH和LH水平下降(P<0.05);B、C组治疗后的改善较A组显著(P<0.05)。结论口服孕三烯酮2.5mg(每周3次)可有效减轻EMS患者疼痛,抑制不规则阴道流血,且对肝功能无显著影响,并可改善生活质量。
Objective To investigate the efficacy of gestrinone in the treatment of moderate and severe endometriosis (EMS). Methods Seventy patients with confirmed EMS were randomly divided into three groups: group A (23 cases) received gestrinone 2.5 mg twice a week from the first day of menstruation; group B (23 cases) received gestrinone 2.5 mg three times per week. Group C (24 cases) took gestrinone 2.5 mg orally three times a week while taking liver protection medicine glycyrrhizin 150mg three times daily for 3 months. The improvement of vaginal irregular bleeding, dysmenorrhea, chronic pelvic pain and painful intercourse were observed. The levels of serum CA125, E2, FSH and LH were measured. Results Compared with those before treatment, the pain symptoms of the three groups were relieved and the irregular vaginal bleeding was decreased. The levels of serum CA125, E2, FSH and LH were decreased (P <0.05) Significant (P <0.05). Conclusion oral gestrinone 2.5mg (3 times a week) can effectively reduce the pain in EMS patients, inhibit irregular vaginal bleeding, and no significant effect on liver function, and can improve the quality of life.