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目的探讨甘精胰岛素联合二甲双胍治疗初诊2型糖尿病患者的临床疗效。方法选取2014年3—9月于沈阳市解放军第四六三医院住院治疗的94例初诊2型糖尿病患者作为研究对象,按随机数字表法将其分为观察组和对照组,各47例。观察组患者皮下注射甘精胰岛素,对照组患者给予门冬胰岛素30,且两组患者均联合口服二甲双胍,比较两组患者治疗前后空腹血糖(FPG)、餐后2 h血糖(2h PBG)、糖化血红蛋白(HBA1c)水平及不良反应发生情况。结果治疗后,观察组患者的FPG、2h PBG、HBA1c水平均明显低于对照组,差异均有统计学意义(均P<0.05);观察组患者低血糖发生率为4.3%(2/47),明显低于对照组的17.0%(8/47),差异有统计学意义(P<0.05)。结论甘精胰岛素联合二甲双胍治疗初诊2型糖尿病,可有效控制患者血糖,明显改善胰岛β细胞分泌功能及胰岛素敏感性,低血糖发生率较低。
Objective To investigate the clinical efficacy of glargine plus metformin in newly diagnosed type 2 diabetic patients. Methods A total of 94 newly diagnosed type 2 diabetic patients hospitalized in the 463 Hospital of Shenyang PLA from March to September in 2014 were selected as study subjects, and divided into observation group and control group according to random number table method, with 47 cases in each group. Patients in the observation group were given insulin glargine subcutaneously, and patients in the control group were given insulin aspart 30, and both groups were given metformin orally. Fasting blood glucose (FPG), postprandial blood glucose (2h PBG), glycosylation Hemoglobin (HBA1c) levels and adverse reactions occurred. Results After treatment, the levels of FPG, 2h PBG and HBA1c in the observation group were significantly lower than those in the control group (all P <0.05). The incidence of hypoglycemia in the observation group was 4.3% (2/47) , Significantly lower than that of the control group (17.0%, 8/47), the difference was statistically significant (P <0.05). Conclusion Glargine and metformin in the treatment of newly diagnosed type 2 diabetes mellitus can effectively control the blood glucose of patients and significantly improve the secretion and insulin sensitivity of pancreatic β cells with low incidence of hypoglycemia.