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目的:调查分析长沙地区232名健康男性志愿者血清抵抗素、脂联素水平与骨密度的关系。方法:随机选择长沙地区汉族健康男性志愿者232名,对调查方案均知情同意,排除患有影响骨代谢疾病、服用影响骨代谢药物者。用酶联免疫吸附试验测定受试者血清脂联素、抵抗素水平;用DXA测定总体、腰椎正位、总髋部骨密度,全身扫描测定体脂水平及瘦体质量。分析血清脂联素、抵抗素水平与体脂及各部位骨密度的关系;利用逐步多元线性回归分析各部位骨密度的影响因素。结果:抵抗素与体脂无相关性。脂联素与体脂呈负相关(r=-0.216,P<0.05),校正年龄与体质量指数后,相关性消失(r=-0.006,P>0.05)。脂联素与总体、腰椎正位、总髋部骨密度呈负相关,校正年龄与体脂后,相关性存在。抵抗素与总体、腰椎正位、总髋部骨密度无相关性。多元线性回归分析显示脂联素是男性各部位骨密度的独立影响因素。结论:抵抗素与体脂及各部位骨密度均无相关性。脂联素与体脂相关,与各部位骨密度呈负相关,是男性各部位骨密度的独立影响因素。
Objective: To investigate the relationship between serum resistin, adiponectin level and bone mineral density in 232 healthy male volunteers in Changsha area. Methods: A total of 232 healthy Han volunteers from Changsha were randomly selected and informed consent was obtained from the investigation. All patients with bone metabolism were excluded from the study. Serum levels of adiponectin and resistin were measured by enzyme-linked immunosorbent assay (ELISA). Total body mass, lumbar spine, total hip bone mineral density (BMD) were measured by DXA. Body fat mass and lean body mass were measured by whole body scanning. The relationship between serum adiponectin and resistin level and body fat and the BMD of each site was analyzed. The influencing factors of BMD of each site were analyzed by stepwise multiple linear regression. Results: There was no correlation between resistin and body fat. There was a negative correlation between adiponectin and body fat (r = -0.216, P <0.05). Correlation between age and body mass index disappeared (r = -0.006, P> 0.05). Adiponectin was negatively correlated with total body, lumbar spine, and total hip BMD. There was a correlation between ADI and body fat. Resistin and overall, lumbar spine, total hip BMD no correlation. Multivariate linear regression analysis showed that adiponectin was an independent factor affecting bone mineral density in all parts of men. Conclusion: There is no correlation between resistin and body fat and BMD of each part. Adiponectin is associated with body fat and negatively correlated with BMD at various sites, and is an independent factor affecting BMD at various sites in men.