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目的探讨Ezrin、IL-6和MMP-9在子宫颈病变组织中的表达及其与癌浸润和转移的相关性。方法采用免疫组化SP法检测了40例子宫颈浸润性鳞状细胞癌、38例原位癌、28例上皮内瘤变和15例正常子宫颈组织中Ezrin、IL-6和MMP-9的表达。结果Ezrin、IL-6和MMP-9在子宫颈浸润性鳞状细胞癌中的表达高于正常对照组及上皮内瘤变组(P<0.05),MMP-9在子宫颈浸润性癌组中的表达高于原位癌组(P<0.05);Ezrin、IL-6和MMP-9在子宫颈浸润性癌中的表达,与子宫颈癌的临床分期和病理分级无关,但均与淋巴结转移有关。结论Ezrin、IL-6和MMP-9在子宫颈浸润性鳞状细胞癌中的高表达与子宫颈癌的侵袭性行为有关,可作为判断早期子宫颈癌预后的指标。
Objective To investigate the expression of Ezrin, IL-6 and MMP-9 in cervical lesions and their relationship with the invasion and metastasis of cervical cancer. Methods Immunohistochemical SP method was used to detect the expression of Ezrin, IL-6 and MMP-9 in 40 cases of invasive cervical squamous cell carcinoma, 38 cases of carcinoma in situ, 28 cases of intraepithelial neoplasia and 15 cases of normal cervical tissue. . Results The expression of Ezrin, IL-6 and MMP-9 in invasive cervical squamous cell carcinoma was significantly higher than that in normal control group and intraepithelial neoplasia group (P <0.05). The expression of MMP-9 in cervical invasive carcinoma (P <0.05). The expression of Ezrin, IL-6 and MMP-9 in cervical invasive carcinoma was not related to the clinical stage and pathological grade of cervical cancer, but both were correlated with lymph node metastasis related. Conclusion The high expression of Ezrin, IL-6 and MMP-9 in invasive cervical squamous cell carcinoma is related to the invasive behavior of cervical cancer and may be used as an index to judge the prognosis of early cervical cancer.