溴克丁(Bromocriptine)为2-溴-α麦角克丁,是一种半合成的麦角碱,由麦角酸基和一环状三肽组成,有特异性兴奋多巴胺受体的长效作用。根据理论,本药应有利于治疗慢性肝性脑病,以前已有1例应用本药治疗成功的报告。本文报道对6例用传统治疗方法未获改善的严重慢性肝性脑病患者,应用溴克丁进行8～12周治疗,然后以双盲法考核疗效,观察患者临床症状、脑电图、脑代谢及脑血液动力学等变化。试验开始时,澳克丁剂量为2.5mg/日,随食物服用;每隔3天递增2.5mg/日,最大剂量为15mg/日。先接受8～12周本药治疗,其后采用双盲法先后交叉应用本药和安慰剂(乳糖)。2例应用安慰剂8周后,再用滇克丁8周;另3例继续应用溴克丁8周后再给安慰剂8周;另1例因很不合作而未继续参加试验。整个试验期间仍使患者继续采用低蛋白饮食和乳果糖甙等治 Bromocriptine is 2-bromo-α-ergocine, a semisynthetic ergot that consists of a lysergic acid group and a cyclic tripeptide, which has the specific long-term effect of stimulating dopamine receptors. According to theory, the drug should be conducive to the treatment of chronic hepatic encephalopathy, there have been 1 cases of the successful treatment of this drug report. This paper reports 6 cases of patients with severe chronic hepatic encephalopathy who have not been improved by the traditional treatment methods, treated with bromocriptine for 8 to 12 weeks, and then double-blind test curative effect, clinical symptoms, EEG, brain metabolism And cerebral hemodynamics and other changes. At the start of the trial, auroradine dose was 2.5 mg / day, taken with food; 2.5 mg / day incremented every 3 days with a maximum dose of 15 mg / day. The first eight to 12 weeks to accept the drug treatment, followed by double-blind cross-application of the drug and placebo (lactose). Two patients were treated with placebo for 8 weeks and then treated with diazepam for 8 weeks. The other 3 patients were given bromocriptine for 8 weeks and then placebo for 8 weeks. The other 1 patient did not participate in the trial because of lack of cooperation. The patient continued to use low-protein diet and lactuloside treatment throughout the trial