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目的:探讨新疆静脉吸毒者中输血传播病毒 (TTV)、乙型肝炎病毒 (HBV)、丙型肝炎病毒 (HCV)感染的特点 ,为防止感染提供理论依据。 方法:采用套式 PCR技术检测 10 2例静脉吸毒者 (IVDUs)血清中 TTV-DNA,用酶联免疫吸附试验 (EL ISA)检测 HCV抗体 (抗 HCV)及 HBV血清学标志物 ,根据 TTV- DNA检测结果分为 TTV - DNA阳性组和阴性组 ,比较两组人群的 HBV、HCV及 HBV/HCV感染情况。结果:静脉吸毒者 TTV-DNA阳性组和阴性组在民族、年龄、性别、吸毒时间、吸毒剂量、有无多性伴侣、HCV和 HBV病毒混合感染等方面无统计学差异 ,而在是否共用注射器上差异有统计学意义 (P <0 .0 5 )。 33例 TTV- DNA阳性静脉吸毒者中 ,7例为单纯 TTV感染 ,2 6例重叠 HCV或 HBV感染 ,其中 TTV、HCV、HBV三重感染 8例。结论 :TTV、HCV在新疆静脉吸毒者中有较高的阳性率 ,静脉吸毒人群是 TTV、HCV感染的高危人群。 TTV可以单独感染 ,但与 HBV、HCV的重叠感染率也较高。
Objective: To investigate the characteristics of transfusion transmitted virus (TTV), hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in intravenous drug users in Xinjiang and provide a theoretical basis for preventing infection. Methods: TTV-DNA in serum of 102 intravenous drug users (IVDUs) was detected by nested PCR. HCV antibody (anti-HCV) and HBV serological markers were detected by enzyme-linked immunosorbent assay (ELISA) DNA test results were divided into TTV - DNA positive group and negative group, HBV, HCV and HBV / HCV infection were compared between the two groups. Results: There was no significant difference in ethnicity, age, sex, drug use time, drug dose, presence or absence of multi-sexual partner, mixed infection of HCV and HBV between positive and negative TTV-DNA groups in intravenous drug users. The difference was statistically significant (P <0. 05). Of 33 TTV-DNA positive intravenous drug users, 7 were pure TTV infection, 26 were overlapping HCV or HBV infection, of which 8 were TTV, HCV and HBV triple infection. Conclusion: TTV and HCV have a high positive rate in intravenous drug users in Xinjiang. The intravenous drug users are at high risk of TTV and HCV infection. TTV can be infected alone, but with HBV, HCV overlapping infection rate is also higher.