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[目的]探讨子宫内膜癌发生的危险因素。[方法]收集2001~2002年海淀区户籍的在北京各大医院就诊并经病理证实为子宫内膜癌的患者临床资料70例。在同一社区人群按照1:3病例对照配比原则进行,对照组进行系统的妇科体检,调查资料进行条件单因素和多因素Logistic分析。[结果]对照组体检确诊子宫内膜癌1例,从对照组剔除。条件单因素Logistic分析显示:职业、肥胖、月经初潮年龄、绝经年龄、不规则阴道出血、子宫内膜异位症为子宫内膜癌的高危因素。多因素Logistic分析显示:绝经年龄、阴道不规则出血是其危险因素。[结论]重视高危因素,对高危人群定期进行妇科检查,可及早诊断和预防癌症的发生。
[Objective] To explore the risk factors of endometrial cancer. [Methods] Seventy-two patients with clinical data of end-stage carcinoma who were registered in major hospitals in Beijing from 2001 to 2002 were enrolled in this study. In the same community, the patients were treated according to the 1: 3 case control matching principle. The control group was given a systematic gynecological examination and the investigation data were subjected to conditional univariate and multivariate logistic analysis. [Results] The control group diagnosed endometrial cancer in 1 case, removed from the control group. Logistic analysis showed that occupational, obesity, menarche age, menopause age, irregular vaginal bleeding and endometriosis were risk factors of endometrial cancer. Multivariate logistic analysis showed that menopausal age and irregular vaginal bleeding were the risk factors. [Conclusion] Paying attention to the risk factors and performing regular gynecological examinations for high-risk groups, it can diagnose and prevent the occurrence of cancer early.