论文部分内容阅读
采用免疫组化方法检测65例食管癌患者肿瘤细胞nm23、p53、PCNA的表达情况。结果:肿瘤分化差伴淋巴结转移者p53呈阳性表达,nm23呈阴性表达;PCNA与食管癌的预后有关,低表达的预后好,高表达的预后较差。结果表明:nm23、p53表达强度与肿瘤分化及淋巴结转移相关,但与预后意义不大,PCNA表达是预测食管癌预后的有效指标之一。
Immunohistochemistry was used to detect the expression of nm23, p53 and PCNA in 65 esophageal cancer patients. Results: Poorly differentiated tumors with lymph node metastasis were positive for p53 and negative for nm23. PCNA was associated with the prognosis of esophageal cancer. The prognosis was good with low expression and poor prognosis with high expression. The results showed that the expression of nm23 and p53 was correlated with tumor differentiation and lymph node metastasis, but had little significance with prognosis. The expression of PCNA was an effective index for predicting the prognosis of esophageal cancer.