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甲氨蝶呤ethotrexate,MTX)用于治疗儿童急性淋巴细胞白血病(acute lymphocytic eukaemia,ALL)已有40余年,是缓解后巩固维持治疗的关键药物,大剂量甲氨蝶?(high dose methotrexate,HD-MTX)尤其对髓外白血病的预防有重要作用,但该疗法毒副作用的发生率较高。本研究改变水化碱化液
Methotrexate ethotrexate (MTX) has been used for the treatment of children with acute lymphocytic leukemia (ALL) for more than 40 years. It is a key drug for remission consolidation and maintenance therapy. High dose methotrexate (HD -MTX) especially for the prevention of extramedullary leukemia has an important role, but the incidence of toxic side effects of this therapy is higher. This study changed the hydration alkalizing solution