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研究观察土耳其碘缺乏区安纳托利亚东北部胃癌与血液和尿液中高浓度的碘是否存在相关性。试验共选入56例胃癌患者和25例健康的对照者。碘浓度检测过程采用Sandell-Kolthoff法。结果显示,与健康对照组比较,胃癌患者尿碘浓度和血浆蛋白结合碘水平均显著性增高。通过测定,Ⅳ期胃癌患者尿碘浓度最高,Ⅲ、Ⅳ期患者比Ⅰ、Ⅱ期高。然而,对于血浆蛋白结合碘水平,Ⅲ期胃癌患者高于Ⅰ、Ⅱ期和健康对照组;Ⅳ期胃癌患者高于Ⅱ期和健康对照组。所有受试者的性别和年龄没有显示出显著的组间差异性。结果提示,可将血液和尿中碘水平作为胃癌患者早期的筛查指标。
To investigate whether there is a correlation between high concentration of iodine in blood and urine of gastric cancer in the northeastern Anatolia in Turkey’s iodine deficiency areas. A total of 56 gastric cancer patients and 25 healthy controls were enrolled. The detection of iodine concentration using Sandell-Kolthoff method. The results showed that, compared with the healthy control group, urinary iodine concentration and plasma protein-bound iodine levels in patients with gastric cancer were significantly increased. Through the determination of Ⅳ, the highest urinary iodine concentration in patients with gastric cancer, Ⅲ, Ⅳ patients than Ⅰ, Ⅱ high. However, for plasma protein-bound iodine levels, stage III gastric cancer was higher than stage I and II and healthy controls; stage IV gastric cancer was higher than stage II and healthy controls. The gender and age of all subjects did not show significant intergroup differences. The results suggest that the blood and urine iodine levels can be used as an early screening indicator of gastric cancer patients.