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目的:了解温州地区不孕妇女生殖道感染的情况及常见病原体分布,探讨生殖道感染与宫颈柱状上皮异位程度、抗精子抗体(AsAb)、抗子宫内膜抗体(EmAb)之间的关系。方法:对227例不孕妇女通过常规妇科检查、病原体分离培养、核酸鉴定,统计生殖道感染率及其主要病原体的感染率,分析生殖道感染与宫颈柱状上皮异位程度、抗精子抗体和抗子宫内膜抗体之间的关系。结果:①227例不孕症妇女共检出生殖道感染116例,感染率为51.1%。解脲支原体感染率为42.2%,念珠菌感染率为23.3%,沙眼衣原体感染率为17.2%,滴虫感染率为8.6%,淋球菌感染率为6.0%,梅毒患病率为1.7%,淋病患病率为0.9%。②宫颈柱状上皮异位中重度妇女解脲支原体、念珠菌和沙眼衣原体感染检测阳性率明显高于轻度宫颈柱状上皮异位,且重度宫颈柱状上皮异位感染检出率高于中度宫颈柱状上皮异位(P<0.05)。③生殖道感染妇女血清AsAb、EmAb阳性率分别为31.9%(37/116)和26.7%(31/116),其中解脲支原体感染组AsAb、EmAb阳性率显著高于沙眼衣原体感染组(P<0.05)。结论:温州地区不孕妇女生殖道感染率较高,特别是解脲支原体、念珠菌和沙眼衣原体感染率高,并与宫颈柱状上皮异位的发生、AsAb和EmAb的高表达有关。
OBJECTIVE: To investigate the prevalence of reproductive tract infections and the distribution of common pathogens in infertile women in Wenzhou, and to explore the relationship between reproductive tract infections and cervical columnar epithelial dysplasia, anti-sperm antibody (AsAb) and anti-endometrial antibody (EmAb). Methods: 227 infertile women were analyzed by routine gynecological examinations, isolation and culture of pathogens, identification of nucleic acid, infection rate of the genital tract and infection rate of their major pathogens. The prevalence of genital tract infection and cervical columnar epithelium was analyzed. Anti-sperm antibodies and anti- The relationship between endometrial antibodies. Results: ①227 infertile women were detected in 116 cases of reproductive tract infection, the infection rate was 51.1%. Mycoplasma urealyticum infection rate was 42.2%, Candida infection rate was 23.3%, Chlamydia trachomatis infection rate was 17.2%, Trichomonas infection rate was 8.6%, Neisseria gonorrhoeae infection rate was 6.0%, Syphilis prevalence rate was 1.7%, Gonorrhea The prevalence was 0.9%. ② The positive rate of Ureaplasma urealyticum, Candida albicans and Chlamydia trachomatis in cervical columnar epithelial ectopic moderate and severe women was significantly higher than that in mild cervical columnar epithelium ectopic, and the detection rate of severe cervical columnar epithelial ectopic infection was higher than that of moderate cervical columnar Ectopic epithelium (P <0.05). (3) The positive rates of AsAb and EmAb in reproductive tract infection women were 31.9% (37/116) and 26.7% (31/116), respectively. The positive rates of AsAb and EmAb in UU infected women were significantly higher than those in Chlamydia trachomatis infection group (P < 0.05). CONCLUSIONS: Infertile women in Wenzhou have a high prevalence of genital tract infections, especially the high infection rate of Ureaplasma urealyticum, Candida and Chlamydia trachomatis, which is related to the occurrence of cervical columnar epithelium ectopic and the high expression of AsAb and EmAb.