从20世纪起,人们慢慢开始不依赖手术治疗消化性溃疡,这导致消化性溃疡复发率升高,直到H2受体拮抗剂的问世,虽然这是一项革命性的发现,但是,复发率依然很高。后来又发现消化性溃疡与幽门螺杆菌的感染密切相关,质子泵阻滞剂联合抗菌治疗的出现才使复发率得到较好的控制。现将质子泵阻滞剂做的临床应用及研究进展简要综述。 From the 20th century onward, people gradually began to rely on surgery for peptic ulcer, which led to increased peptic ulcer recurrence until the advent of H2 receptor antagonists, although this is a revolutionary discovery, but the recurrence rate Still high. Later found that peptic ulcer and Helicobacter pylori infection are closely related to the proton pump inhibitor combined with antimicrobial therapy appears to make the recurrence rate better control. The proton pump blockers now do a brief review of the clinical application and research progress.