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由于PGE_1治疗皮肤溃疡经动脉注射操作困难,静点给药量的70～90%在肺内失活,现用量常达到40～120μg。所以作者采用不经肺脏直达病灶部位的PGE_1局注疗法。方法:PGE_120～40μg 溶于5～10ml 生理盐水中,直接、少量注入褥疮壁内和肉芽面。而且通过病理组织学和温度测量法进行了深入研究。对4例难治性褥疮患者的治疗结果表明:①局注后短期内(3天～3周)即有褥疮表面肉芽增生和创面缩小。②组织学观察到肉芽的毛细血管扩张和出现新生血管。③如PGE_1局注剂量过大,可出现玻
As PGE_1 treatment of skin ulcers by arterial injection difficult to operate, intravenous administration of 70 to 90% in the lung inactivation, the amount often used to reach 40 ~ 120μg. Therefore, the author uses the PGE_1 treatment without direct lung lesions. Methods: PGE_120 ~ 40μg was dissolved in 5 ~ 10ml normal saline, injected into the wall of the bedsore and the granulation surface directly. But also through in-depth study of histopathology and temperature measurement. The results of treatment of 4 patients with refractory bedsore showed that: (1) there was surface granulation proliferation and wound shrinkage of bedsore in a short period of time (3 days to 3 weeks) after the injection. ② histology observed granulation of the telangiectasia and neovascularization. ③ If PGE_1 Bureau injection dose is too large, there may be glass